## Varicella Emulator

We establish the power of our approach with a high dimensional model from van Hoek et al (2012) with correlated inputs to explore cost-effectiveness of varicella-zoster vaccination programs. With symbolic regression, we selected 12 driving parameters from the 185 inputs. Here, the interactive prediction plots for the gain in quality adjusted life years (QALYs) are shown (Legend).

## Legend Varicella

- chi_allages
- Change in Zoster reactivation in Varicella vaccinees versus non vaccinees (chi) (%).
- durboost_allages
- Average duration of natural protection from herpes zoster after varicella re-exposure (year).
- takzos_7579
- Zoster vaccine uptake for ages 75-79y (effective protection by the vaccine) (%).
- wanzos_allages
- Average duration of protection from herpes zoster vaccine (year).
- to2_10
- Probability of a +65y to infect a 2-3y old per year (based on a social contact matrix from UK study population combined with age-specific transmission rates).
- to2_9
- Probability of a 45-64y to infect a 2-3y old per year.
- to3_10
- Probability of a +65y to infect a 4-10y old per year.
- to3_9
- Probability of a 45-64y to infect a 4-10y old per year.
- to4_8
- Probability of a 35-44y to infect a 11-16y old per year.
- to5_10
- Probability of a +65y to infect a 17-21y old per year.
- to8_10
- Probability of a +65y to infect a 35-44y old per year.
- to8_8
- Probability of a 35-44y to infect a 35-44y old per year.